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Evaluation of Polymorphnuclear Leucocyte Elastase as Diagnostic Tool in Neonatal Sepsis

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Last updated: 24 Dec 2024

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Abstract

Objectives: Neonatal sepsis is clinical syndrome of bacteremia with systemic signs and symptoms. Neonatal sepsis is still a leading cause of mortality in neonatal intensive care units all over the world. Early diagnosis and treatment of the newborn infant with suspected sepsis are essential to prevent severe and life threatening complications.
Objective: The aim of this study was to evaluate polymorph nuclear (PMN) leucocyte elastase as a diagnostic tool in neonatal sepsis.
Subjects and Methods: This study was conducted on 45 full term and preterm neonates suspected as neonatal sepsis compared to 45 apparently healthy neonate with matched age and sex, as a control group.
Results: 55.6% of our patients group were full-term patients and 44.4% were preterm. All the patients were subjected to full history taking, full clinical examination, lab investigation including CBC, CRP, blood culture and sensitivity, and measurement of serum polymorph nuclear leucocyte elastase enzyme.
Conclusion: Significant elevation of serum polymorph nuclear leucocyte elastase level in neonatal sepsis with high specificity.

DOI

10.21608/ejhm.2018.9087

Keywords

Polymorphonuclear leucocyte, Escherichia coli, Early onset sepsis, Late onset sepsis

Authors

First Name

1Bothina Mohamed Abdel-Aziz El-Nagar, 1Soheir Ibrahim Mohamed,

Last Name

2Sabah Ibrahim Abdelrahim, 1Mohamed Abdel-Gawad Morsy

MiddleName

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Affiliation

1Department of Pediatrics, 2Department of Clinical Pathology, Faculty of Medicine for Girls - Al Azhar University

Email

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Volume

72

Article Issue

2

Related Issue

1774

Issue Date

2018-07-01

Receive Date

2018-07-14

Publish Date

2018-07-01

Page Start

4,000

Page End

4,004

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 72_Issue 2_Pages 4000-4004.pdf

PDF . 223.8kB

Link

https://ejhm.journals.ekb.eg/article_9087.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=9087

Order

23

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Evaluation of Polymorphnuclear Leucocyte Elastase as Diagnostic Tool in Neonatal Sepsis

Details

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Article

Created At

22 Jan 2023