Background: Hepatitis C virus is an RNA virus that cause acute and chronic infection. The chronic infection can cause progression to several critical diseases including liver cirrhosis and hepatocellular carcinoma. The prevalence of the virus is increasing and as a result the related diseases and mortality increase. Prevention of the new infections and treating the patients can result in decreasing in number of new cases and avoiding mortality. Aim: To study the prevention measures for HCV infection and its related chronic diseases. Methods: Internet was used to search for articles related to the current subject using different keywords and different scientific websites. Results: There were 7 articles included in this review including both research and review articles. Conclusion: HCV and its related chronic diseases can be prevented by several available strategies such as increasing knowledge and awareness about HCV, screening of population under high risk and treatment of patients.