Background: Proton pump inhibitors are substituted benzimidazoles compounds, they are used as agents for the treatment of acid-peptic diseases. These compounds are metabolized by several enzymes, the genetic variations in these enzymes were thought to influence the pharmacogenetics of the proton pump inhibitors and in turn influence the outcome of the patients. Aim: To highlight the pharmaco-genetics of proton pump inhibitors Methods: Scientific websites were used to search for articles such as Pubmed and Google Scholar. Several keywords were used to obtain all possible articles concerned with the subject. Results: We reviewed 6 articles about the current subject, there were few articles about the pharmacology of proton pump inhibitors. Conclusion: Few studies have focused on the pharmacogenetics of proton pump inhibitors and most of them were trials, also there were no previous review articles studied this subject.