Aim of the work: this study aimed to detect the histological and histochemical changes in liver tissue of pregnant rats and their fetuses after treatment with carisoprodol. Material and methods: thirty pregnant female rats were randomly categorized into three groups (ten pregnant female rats in each group). The first was administered oral doses of distilled water and was served as control. The other two groups were administered oral doses of carisoprodol in the distilled water equivalent to 10.8 mg and 21.6 mg/100g body weight/day respectively for 15 days from the 6^th day to the 20^th day of gestation. Numerous histological and histochemical studies were done to detect the histopathological and histochemical changes. Results: maternal and fetal liver tissue of both treated groups showed lots of degenerative changes post-treatment withcarisoprodol. The severity of these changes was more obvious in fetal liver tissue of both groups this was accompanied with numerous histochemical changes. Conclusion: treatment of pregnant rats withcarisoprodol led to numerous dystrophic changes in maternal and fetal liver tissue.