Splenomegaly is a common sequela of cirrhosis and is frequently associated with decreased hematologic indices including thrombocytopenia and leukopenia. Partial splenic artery embolization (PSE) has been demonstrated to effectively increase hematologic indices in cirrhotic patients with splenomegaly. This is particularly valuable amongst those cirrhotic patients who are not viable candidates for splenectomy. Purpose: This study aims to discuss the role of partial splenic artery embolization in the treatment of the decreased hematologic indices including thrombocytopenia and leukopenia in chronic liver disease and the efficacy of this method in increasing of hematologic indices in cirrhotic patients with splenomegaly Patients and methods: twenty-five patients with chronic liver disease were included. All patients had chronic liver disease with hypersplenism and hyperactive bone marrow and all patients underwent PSE in one session then follow-up after one month was done. Results: The mean age of the selected patients was about 46years old. All patients showed significant increase in the platelet count after one session and remained at appropriate levels during the follow up period. Postembolization syndrome was the most common complication and occurred in all patients (100%). Ascites developed in 4 patients (16%). Portal vein thrombosis developed in 2 patient (8%) Splenic abscess developed in 1 patient (4%). No other complications have been reported. None of the patients developed septic shock. No post procedure mortality occurred. Conclusion: Partial splenic artery embolization is an effective method for the treatment of hypersplenism caused by chronic liver disease and safer than splenectomy as it results in improvement of the hematological status with preservation of immunological role of the spleen.