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Comparative Randomized Controlled Blind Study of the Anti-Shivering Effect of Hydrocortisone, Granisetron and Meperidine in Post-Spinal Anesthesia in Patients Undergoing Cesarean

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Last updated: 03 Jan 2025

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Abstract

Background: it was observed that a considerable proportion of patients undergoing surgery experience intraoperative and postoperative hypothermia and it was found that misregulation of body temperature due to anesthesia as well as the cold temperature of the operation room were the main cause.
Purpose: to compare the anti-shivering effect of meperidine, hydrocortisone and granisetron after spinal anesthesia during elective cesarean section. Patients and Methods: this study presents a placebo-controlled prospective randomized blind study. Included patients were randomly (using computer generated randomization table) allocated into four equal groups each group consists of 28 patients. Results: in our study, age, sex, and ASA grade distribution of patients were nearly identical in the four groups. Furthermore, the duration of surgery and amount of irrigation fluid used in the four different groups were also similar. We did not observe a change in temperature gradient between the four groups. A study with a more prolonged duration of postoperative temperature monitoring is needed to note if core-periphery temperature changes occur with passage of time. Conclusion: the results indicate that IV granisetron 40 μg/kg was effective as IV meperidine 0.4 mg/kg and both are slightly effective than IV hydrocortisone 2 mg/kg in reducing the incidence and intensity of shivering during spinal anesthesia compared to control group.

Keywords

Anti-shivering, Hydrocortisone, Granisetron – Meperidine, cesarean section, Post-spinal Anesthesia

Authors

First Name

Mohamed Sidky Mahmoud Zaki, Ahmed Mohamed El Sayed El Hennawy,

Last Name

Yahia Mamdouh Hassan Mekki, Moustafa Atef Moustafa Hamouda

MiddleName

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Affiliation

Department of Anesthesiology, Intensive Care Medicine & Pain Management Faculty of Medicine, Ain shams University

Email

moustafaatef.13b@gmail.com

City

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Orcid

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Volume

71

Article Issue

3

Related Issue

1663

Issue Date

2018-04-01

Receive Date

2018-03-20

Publish Date

2018-04-01

Page Start

2,759

Page End

2,764

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 71_Issue 3_Pages 2759-2764.pdf

PDF . 374.3kB

Link

https://ejhm.journals.ekb.eg/article_8691.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=8691

Order

19

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Comparative Randomized Controlled Blind Study of the Anti-Shivering Effect of Hydrocortisone, Granisetron and Meperidine in Post-Spinal Anesthesia in Patients Undergoing Cesarean

Details

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Article

Created At

22 Jan 2023