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Role of Botulinum Toxin Type A in Management of Vocal Fold Contact Granuloma Meta-Analysis Study

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Last updated: 03 Jan 2025

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Abstract

Background: granulomas of the vocal process of the larynx are benign lesions of the posterior glottis generally centered over the tips of the cartilaginous vocal processes. Clinically they are associated with odynophagia, throat clearing, globus, and otalgia.
Aim of the Work: this meta-analysis study aimed to know the role of botulinum toxin type A in management of vocal fold contact granuloma.
Materials and Methods: this study strictly followed the recommendation of referred reporting items for systematic reviews and meta-analyses (PRISMA) statement. It was done in the following steps: target determination, identification the location of articles, screening and evaluation, data collection, data analysis and finally reporting and interpretation. Results: there was acceptable complete response rate of contact granuloma to botulinum toxin injection with event rate of 85.422% while rate of improvement among selected cases was 92.962%. Concerning to complications the most common complication was hoarsness of voice with rate of 52.737% while dysphagia was 21.125% among cases. Conclusion: botulinum toxin is a safe and effective therapy in resolving vocal process granulomas. Complete response and partial response are significant in our study also decreased Valsalva effort, failure rate and relapse rate are all significant outcomes. While temporary post injection hoarsness of voice, dysphagia, local pain at injection sites and fluid aspiration considered non significant outcomes.

Keywords

Botulinum toxin type A, vocal fold contact granuloma

Authors

First Name

Ahmed A. Mohamed, Amr N. Rabie, Marwa M. ElBegermy,

Last Name

Wael A. Sobih

MiddleName

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Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Ain-Shams University

Email

dr_waelsobeh86@yahoo.com

City

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Orcid

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Volume

71

Article Issue

4

Related Issue

1654

Issue Date

2018-04-01

Receive Date

2018-03-20

Publish Date

2018-04-01

Page Start

2,963

Page End

2,973

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 71_Issue 4_Pages 2963-2973.pdf

PDF . 569.7kB

Link

https://ejhm.journals.ekb.eg/article_8655.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=8655

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16

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Role of Botulinum Toxin Type A in Management of Vocal Fold Contact Granuloma Meta-Analysis Study

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Type

Article

Created At

22 Jan 2023