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Rice Bran Oil Ameliorates Hepatic Insulin Resistance in Fructose Fed-Rats

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Last updated: 03 Jan 2025

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Abstract

Background: Insulin resistance is a pathological condition characterized by inadequate peripheral tissue metabolic response to circulating insulin. High dietary fructose causes insulin resistance syndrome, primarily due to simultaneous induction of genes involved in glucose, lipid and mitochondrial oxidative metabolism. Rice bran oil (RBO) is a rich source of antioxidants which contribute to higher oxidative stability and longer shelf life than other edible oils. Aim of the work: The current study investigated the effects of the daily intake of RBO on insulin resistant rat liver, as a central organ in carbohydrate metabolism.
Materials and methods: Rats were allocated in 5 groups. Animals in groups 1 and 2 received standard diet and standard diet containing RBO, respectively. Group 3: animals fed high fructose diet (HFD), which was categorized into: rats fed HFD either for one month (HFD1) or for 2 months (HFD2). Group 4, rats were fed HFD containing RBO for one month (HFD1+RBO), while rats in group 5 were fed HFD for 30 days then RBO was added to the diet for another 30 days (HFD2+RBO). Results and conclusion: addition of RBO to this model improved insulin sensitivity in liver.

Keywords

Insulin Resistance, rice bran oil, glycogen

Authors

First Name

Sohaier A. Abd Elbast1, Mona A. Mohamed2*,

Last Name

Mervat A. Ahmed1, Nehad A. Ali1

MiddleName

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Affiliation

1Zoology Department, Faculty of Science, Al-Azhar University, Cairo, 2Biochemistry Division, Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt

Email

toyoralgannah2013@yahoo.com

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Volume

71

Article Issue

4

Related Issue

1654

Issue Date

2018-04-01

Receive Date

2018-03-20

Publish Date

2018-04-01

Page Start

2,885

Page End

2,891

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 71_Issue 4_Pages 2885-2891.pdf

PDF . 702.2kB

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https://ejhm.journals.ekb.eg/article_8630.html

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https://ejhm.journals.ekb.eg/service?article_code=8630

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Rice Bran Oil Ameliorates Hepatic Insulin Resistance in Fructose Fed-Rats

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Article

Created At

22 Jan 2023