Background: Office hysteroscopic examination is now an established step in the diagnostic work up of cases with abnormal uterine bleeding, infertility, and recurrent miscarriage that can be performed safely and efficiently without anesthesia in most cases. Objectives: This study aimed at assessment of the efficacy of the use of platelet rich plasma (PRP) in decreasing occurrence and recurrence of intrauterine adhesions after operative hysteroscopy. Patient and Methods: This study was conducted in Ain Shams Maternity Hospital (Early Cancer Detection and Endoscopy Unit) during the period between January 2017 and February 2018. 60 patients seeking for conception with a history of primary or secondary infertility with sever intrauterine adhesions. 30 patients (case) injected with PRP and 30 patients (control) with IU balloon. All patients had normal complete blood count, and not taking anticoagulant or NSAID in the 10 days before procedure with no active cervical or uterine infection. Results: It was found that the mean age in PRP group was 31.8 ± 4 years old and balloon group was 30.5 ± 4.7 range: (20-45 years old). The mean of BMI in PRP group was 24.4 ± 2.2 and balloon group was 25.1 ± 2.4. In this PRP group (13.3%) of patients were nulliparous and balloon group (10%), (86%) of PRP group are multipara and in balloon group (90%). There was no significant association between ages, parity with any possible etiology. Our study showed significant increase of menses duration among the PRP group post-operative (3.0 ±1.2) days and preoperative menses duration (1.4 ± 1.5) days. Compared to balloon post-operative (1.8 ± 1.3) and preoperative (1.3 ± 1.4) days. Conclusion: platelet rich plasma had high efficacy and safety in improvement of menses duration, amount and adhesion score in cases of sever intrauterine adhesions and decreasing postoperative adhesions.