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Value of Midkine as a Diagnostic Serum Marker in Hepatocellular Carcinoma

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Last updated: 24 Dec 2024

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Abstract

Background: hepatocellular carcinoma (HCC) represents a global health problem. It is the fifth most common cancer but the second leading cause of cancer-related death in men worldwide. In Middle Eastern countries, liver cancer is a major concern among men, especially in Egypt and Saudi Arabia. The incidence of HCC has increased sharply in the last 5–10 years, with an especially high incidence in Egypt. So, early detection and diagnosis of these cases are required for successful treatments and improved outcomes. Aim of the Work: this study aimed to detect the efficacy of serum level of Midkine as an early marker for HCC diagnosis compared to AFP serum level. Patients and Methods: this prospective study was conducted on a total of 50 subjects, 30 of them with HCC and 20 apparently healthy subjects matched for age and sex with patients. It was carried out at the Clinical Pathology Department, Tanta University Hospital. Results: a significant increase (p < 0.001) in serum midkine level was detected in HCC group compared with control group from a mean of 391.45 ± 96.09, in control group to a mean of 1074.53 ± 106.27, in HCC. Conclusion: serum midkine may serve as a novel diagnostic tumor marker for the detection of hepatocellular carcinomas. Recommendations: it was recommended to do further studies on early cases with larger population including AFP-negative patients, to justify its implementation in clinical practice.

Keywords

Hepatocellular carcinoma, Midkine, alpha-fetoprotein

Authors

First Name

Desouky E. Abou Ammo 1 , Ashraf F. Barakat 2,

Last Name

Amira Y. Ahmad 1 , Rehab R. Farag 1

MiddleName

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Affiliation

1- Department of Clinical Pathology, 2- Department of oncology, Faculty of Medicine, Tanta University

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Volume

71

Article Issue

5

Related Issue

1649

Issue Date

2018-04-01

Receive Date

2018-03-20

Publish Date

2018-04-01

Page Start

3,179

Page End

3,183

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 71_Issue 5_Pages 3179-3183.pdf

PDF . 279.1kB

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https://ejhm.journals.ekb.eg/article_8595.html

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https://ejhm.journals.ekb.eg/service?article_code=8595

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17

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Value of Midkine as a Diagnostic Serum Marker in Hepatocellular Carcinoma

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Article

Created At

22 Jan 2023