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Dose Response Effect of Nitroglycerin on Cardiac Hemodynamic Functions and Myocardial Infarction in a Rat Model of Ischemia Reperfusion

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Last updated: 03 Jan 2025

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Abstract

Background: Millions of people suffer from acute coronary syndrome, angina, acute myocardial infarction (MI), or related illnesses. These patients are prescribed nitroglycerin (NG) for the management of these diseases. Accordingly, any risk associated with the use of nitroglycerin can potentially affect those people despite of the undeniable benefit in relieving acute angina. Aim of the present work: was to study the potential of treatment with 3 different doses of NG (25, 50, 100 mg/kg) to develop nitrate tolerance.
Materials and Methods: 50 Male Albino rats were randomly divided into 2 main groups: sham group and ischemia/reperfusion (I/R) groups, which was further subdivided into 4 groups, Untreated group; NG 25, 50 and 100 mg groups; rats received nitroglycerin three times daily for 3 days before induction of ischemia reperfusion. the effect of NG on cardiac functions and infarction size and severity score were assessed. Results: Rats exposed to I/R exhibited a significant decrease in their cardiac hemodynamic functions (↑ left ventricular end diastolic pressure; LVEDP and ↓dp/dtmax) and development of a measurable cardiac infarction area. Regarding pretreatment with NG; NG 25 mg/kg improved cardiac functions and myocardial infarction size & severity score. NG 50 mg/kg significantly decreased myocardial contractility and increased myocardial infarction size. Meanwhile NG 100 mg/kg produced significant decrease in cardiac functions and significant increase in myocardial infarction size & severity score.
Conclusion: NG pretreatment dose dependently decreased cardiac hemodynamic functions and increased myocardial infarction size & severity score in a rat model of ischemia reperfusion.

Keywords

Nitroglycerin, Cardiovascular System, LVEDP, LV dP/dtmax, Ischemia/reperfusion

Authors

First Name

Nada Kotb Abd Elfatah Kotba, Amany H Hasanina, Nevien Fekry Abdalla Hendawya,

Last Name

Naglaa Samir Ahmedb and Ahmed Nour Eldin Hassana.

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Affiliation

Departments of aClinical Pharmacology, and bPathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

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Volume

71

Article Issue

5

Related Issue

1649

Issue Date

2018-04-01

Receive Date

2018-03-20

Publish Date

2018-04-01

Page Start

3,142

Page End

3,147

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 71_Issue 5_Pages 3142-3147.pdf

PDF . 563.0kB

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https://ejhm.journals.ekb.eg/article_8589.html

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https://ejhm.journals.ekb.eg/service?article_code=8589

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Dose Response Effect of Nitroglycerin on Cardiac Hemodynamic Functions and Myocardial Infarction in a Rat Model of Ischemia Reperfusion

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Article

Created At

22 Jan 2023