Background: High uric acid level used to predict many diseases including left atrial thrombus, it may indicate aspirin-resistant patients. It could be also used as a biochemical index for diagnosing adolescence depression. High uric acid level is a known risk factor for deterioration of renal function in chronic kidney disease. It is also as a risk factor for cardiovascular disease and found to be associated with increased arterial stiffness Aim: is to investigate the independent association between serum uric acid and lipid profiles. Methods: Cross sectional study conducted over 200 patients who attended the various out-patient department of Prince Sattam Bin Abdulaziz University Hospital Al Kharj in Saudi Arabia. The data included individuals between 20 and 75 years old with lab test within the last year. Results: The data showed that the highest level of uric acid was in patients older than 50 years old (394 SD ±77.77) and it decreased in proportionate. The data showed significant association between the uric acid and the triglyceride (P = 0.003) and no significant association with the total cholesterol (P= 0.511). It also revealed no significant differences between the antihypertensive as well as antidiabetic groups and normal patients (P = 0.520 and 0.594 respectively). Conclusions: There is strong association between the uric acid and triglyceride, while high level of uric acid is not associated with high level of total cholesterol. The antidiabetic as well as antihypertensive drugs have significant effect over the triglyceride level while there is no significant effect on the TC level and the UA.