Obesity, especially the visceral one, insulin resistance, atherogenic dyslipidemia, and hypertension are considered metabolic disorder, but the constellation of at least three of these metabolic disorders can be identified collectively as metabolic syndrome (MetS), The prevalence of this syndrome is mostly driven by the current changes in the social environment, behavior, and lifestyle, which is generally called a sedentary lifestyle since more and more individuals are being diagnosed with it.The main target of this article is the collection of some available known published papers aboutthe evaluation of dietary induction of metabolic syndrome accompanied with MTHFR rs1801133(MTHFR–Ala222Val)Singlenucleotide polymorphism (SNP) and the potential preventive effect of metformin or curcumin in male albino rat with an induced MetS as a novel method using many biochemical, Anthropometrical, and molecular biological tests including the embedding the RFLP technique for identification of the presence of the target SNP and its role both in the induction of this gene polymorphism and its role in MetS treatment.