The present research was designed to study the positive effect of curcumin and the bad effects of dietary high fat diet (beef tallow) which causes  nonalcoholic fatty liver disease, very harmful affecting health, also our study was designed to study the important role of curcumin, against (HFD-induced obesity). Sixty male albino rats weighing( 165-170gm), were be  obtained  from  animal house at the Faculty of Veterinary Medicine ,Zagazig University .After acclimatization at 23-25 ⁰Cand and free availability of water and diet rats were divided into four main groups, each contains 15 rats for 12  weeks.G1(Control),G2(Curcumin),G3(HFD),G4(HFD+cur) .At the end of the experiment, all rats were euthansized and blood collected weekly  to biochemical examination during 12 weeks.  Our results after statistical analysis revealed that  showed that rats Fed on curcumin (3% w/w), had a significant increase in (total glutathione ,GSH, glutathione quotient) and a significant decrease in oxidized glutathione level in hepatic tissue ,a significant increase in the activity of liver glutathione peroxidase and reductase but a significant decrease in the glutathione state in rats fed on beef tallow on G3 (HFD)  when compared to the control group .a significant increase in glutathione state in G4(HFD+CUR) when compared to G3(HFD). our results revealed a significant increase in insulin level ,HDL ,and a significant decrease  in blood glucose, TAG, total cholesterol ,MDA ,LDL in G2(Curcumin) and (HFD+CUR) but a small significant  decrease in total bilirubin in only (HFD+CUR) group when compared to group 3(HFD). A significant decrease in insulin level, HDL-c in G3(HFD)when compared to curcumin group a significant increase in blood glucose, TAG , TC ,LDL-c ,VLDL, MDA, bilirubin in high fat diet .Rats fed on curcumin 3% showed a significant decrease in body weight gain but rats fed on beef tallow revealed a significant increase in body weight.