Developed multidrug resistant bacteria (MDR) in the field of poultry industry lead to the wide use of combined antimicrobials against enterobactericeae infections. This study deal with benefit drug interactions for use in broiler industry. A total of 75 samples were collected from visceral organs of diseased broilers. Fivty isolates of enterobactericeae were recovered and biotyped as 32 E. coli, 12 Salmonellae and 6  Klebsiellae. Antibiogram revealed frequent sensitivity to colistin, cefotaxime and gentamycin. Meanwhile, all isolates were resistant to erythromycin and Nigella sativa oil. The isolates with intermediate sensitivity to any of the tested antimicrobial were examined for combined interactions of synergism. Fractional inhibitory concentration of two combined antimicrobials was detected. There was synergism between colistin with  floriphenicol, ciprofloxacin, doxycyclins and amoxicillin. In addition, to synergism between gentamycin with cefotaxime, doxycyclin and erythromycin. Fractional inhibitory concentration of two anti-microbials with synergism was less than 0.50. Nigella sativa oil showed no synergism with any one the tested antimicrobials. It could be concluded that MDR enterobacteria with resistance to all antimicrobials could be susceptible to several of two combined antimicrobials.