Eighty turkey poults 20 days old were equally divided into 4 equal groups to evaluate the efficacy of Apramycin against the colibacillosis; group1 was kept as control, group 2 received 25mg/kg.b.wt. of Apramycin in drinking water for 5 successive days, the group3was infected with 3×10⁹ organisms of E.coli (O78)and group 4 was infected with E.coli and treated with Apramycin .Five poults from each group was sacrificed,1,15 and 20 day from the beginning of the experiment.
Two blood samples were taken and the serum was separated for hematological and biochemical studies. Tissue specimens were collected for drug- residues assessment and for pathological examination. The poults of group3 shows significant decrease in RBCs, Hb ,PCV% ,total proteins ,albumin ,globulins with insignificant increase in A/G ratio. and significant elevation in WBCs ,AST ,ALT ,ALP, Uric acid and Creatinine These changes were lowered in group 4.The highest Apramycin residues were present in the kidneys ,liver, skin and thigh muscles ,respectively, then disappeared completely rom the examined organ samples after 20 days post treatment. The pathological examinations were coincided with the biochemical examination these changes included degenerative changes in hepatocytes, epithelial lining of renal tubules in addition to coagulative necrosis in both hepatic and renal parenchyma. Congestion and leukocytic infiltrations were noticed. Finally, it could be concluded that the Apramycin is effective against the Colibacillosis, in turkey poults.