Foot and mouth disease virus (FMD) had taken an enzootic form in Egypt since 1950, since then continues outbreaks occurs, serotype A, O and SAT2 are the most common serotypes isolated in Egypt. In this study, The suspected isolates were diagnosed and typed using an RT - PCR test. The nucleotide sequences of the VP1-coding region was determined and phylogenetic analysis was performed. The results showed that FMDV serotype O were confirmed to be serotype O topotype ME-SA in all localities,while the isolated type A during 2009 was confirmed to be serotype A topotype Africa, while the isolated type A during 2010 and 2011 belong to the Asia topotype and FMDV serotype SAT was confirmed to be SAT2 topotype VII.