The present study was designed to investigate the protective role of vitamin E against gentamicin toxicity. A total of 80, 4 weeks -old turkey poult were divided into 4 groups. 1^st group healthy non-treated turkeys (control group), 2^nd group gentamicin (5mg/kgm B.wt/day) treated, 3^rd group vitamin E ( 10mg/kg B.wt/day) treated, 4^thgroup treated with gentamicin plus vitamin E. Five turkeys poults from each group were sacrificed at1^st day post treatment, blood samples and Specimen from internal organ were taken for hematobiochemical and histopathological study. Five turkey poults from each group were weighted at start and 1^st day post treatment for detection effect of the durgs in body weight. 
The present work revealed that, gentamicin  induced a significant reduction in RBCs count, Hb, PCV %, total protein, albumin, globulin and rise in AST, ALT, ALP, uric acid, and creatinine beside insignificant rise in WBCs count and body weight in turkey at 1^stday post treatment. Vitamin E induce significant rise in RBCs count, Hb, PCV % total WBCs count, total protein, albumin globulin and insignificant increase in body weight, AST, ALT, ALP, uric acid, creatinine and body weight in turkey at 1^stday post treatment.
Necropsy revealed swollen kidneys and liver with hemorrhagic streaks on its surface. Petechial hemorrhages present on skeletal muscles. Microscopically, kidneys showed degenerative changes and necrosis of the renal tubules. Liver showed severe vacuolar and hydropic degeneration of the hepatic parenchyma.
Oral administration of vitamin E to turkey poult gentamicin treated caused improvement in hematobiochemical parameters and pathological lesions.
From the results, it can be concluded that gentamicin is a highly toxic to turkey birds but vitamin E has potential protective effects against gentamicin toxicity.