The efficacy of different living attenuated commercial vaccines against IBDV was tested in ten groups of (20) Specific Pathogen Free chicks (SPF) for monitoring the immunosuppression effect. The immune responses were determined in nine groups of (25) “for each group", two weeks old SPF chicks in-vitro through application of Enzyme Linked Immunosorbent Assay (ELISA) and Serum Neutralization Test (SNT) titers post vaccination with evaluation of bursa/body weight ratio and histopathological examination of bursa of Fabricious; then in-vivo by challenging of birds with 10^3.5 EID₅₀/dose challenge IBD virus strains (variant; classical and very virulent strains).The obtained results revealed that protection percentages were ranged between 90%-100% in birds vaccinated with intermediate or intermediate plus IBD vaccine and between 90%-95% in birds vaccinated with invasive intermediate Bursa B2K, while birds vaccinated with classical D78 showed protection of 95%-100% with highest ELISA and SNT mean titers as “11344 and 1024", respectively. This confirms that under field condition, poultry industry can be protected from IBDV disease using commercial IBD vaccine strains in correct time and condition according to status of flock and location of farm.