Twenty five Rabbits were collected and showed, Eimeria stiedae Oocyst from both fecal and liver smears (40%) when examined microscopically. Naturally infected rabbits showed emaciation, diarrhea and yellowish white colour nodules on the liver. Forty rabbits of two months age were divided into 4 groups; one kept as control, the last 3 groups were infected with the isolated oocyst and each rabbit received 100000 sporulated oocyst per 3ml. The orally infected group only showed severe signs as diarrhea, decrease in body weight, loss of appetite and 30% mortality. Moreover, damaged and enlarged liver with hepatomegally, yellowish white nodules on the surface and severe histopathological lesions in liver and bile duct. Group treated with 4% Neem extract  (Herbal anticoccidial) showed normal body weight which increased post treatment and improved the liver function (AST and ALT), while group treated with Toltrazuril showed a significant increase in body weight more than the control group. Also, liver function improvement was more responded with no symptoms in both treated groups.