Spread of multidrug resistant (MDR) bacteria in meat products has great impact on human health. Twenty E. coli, 10 Salmonella and 25 S. aureus isolates, recovered from 250 retail meat samples purchased from various supermarkets in Zagazig, Egypt, were assayed for antimicrobial susceptibilities, antimicrobial resistance genes and the presence of class 1 integrons. Frequent resistance to amoxicillin- clavulanic acid and erythromycin was detected in E. coli and Salmonella. Meanwhile, S. aureus was frequently resistant to clindamycin, chloramphincol, erythromycin and sulfamethoxazole-trimethoprim. 10 E. coli, 6 Salmonella and 12 S. aureus exhibited multidrug resistance phenotypes (resistant to 3 drug or more). Eight out of 25 S. aureus isolates (32%) were MDR and vancomycin resistant (VRSA) with MIC ranged from 64 to 1024 µg/ml. Van A, van H, van S and van B were implicated in isolates of the area under study.  Class 1 integron was detected in 9/16 (56%) MDR isolates of E. coli and Salmonella. Nevertheless, all VRSA contains no integron. These results highlighted the role of retail meat as a potential source for multidrug-resistant E. coli, Salmonella and VRSA