An experiment was conducted to study the effect of dietary supplementation with pomegranate peel (Punica granatum L) extract (PPE) on growth performance, serum lipids profile and immunity response as serum lysozyme content in broiler chickens. A total of 90, one day old Cobb broiler chicks were used. Birds were allotted into three experimental groups; each group allotted into 3 subgroups, 10 chicks /replicate. Group I was fed on basal diet, group II was fed on basal diet supplemented with 0.05 g PPE /kg of the diet and group III basal diet supplemented with 0.1 g PPE /kg of the diet. Body weight and feed intake were determined weekly. Body weight gain and FCR were calculated. After the end of the trial, 3 birds from each group were slaughtered for collection of the blood. The result of the showed no significant differences (P < 0.05) between all groups in body weight, weight gain, feed intake and FCR. Liver, heart and abdominal fat percent were significantly decreased (P < 0.05) in group II and group III. Total cholesterol and LDLP- cholesterol concentration in serum were significantly decreased (P < 0.05) in group II and group III, while HDL- cholesterol concentration were significantly increased (P < 0.05) in group II and group III, also triglycerides and VLDL- cholesterol were significantly decreased (P < 0.05) in group III only. Lysozyme content (µg / ml) was significant increased (P < 0.05) in group II and group III in compared to control group.