50986

Hepatic and Renal Protective Effects of Annona muricata Leaf and Fruit Extracts on Ehrlich Ascites Carcinoma in Mice

Article

Last updated: 03 Jan 2025

Subjects

-

Tags

Academic and Pre-clinical Veterinary Sciences (Physiology, Histology, …rology, Parasitology, Pharmacology, Forensic Medicine and Toxicology)

Abstract

Cancer is a complicated disease incorporating many factors and causes which could be environmental, metabolic disorder, chemical, and genetic alteration. Many of the already used anticancer therapies are derivatives of natural sources including herbs. The current study was designed to assess the antitumor activity of Egyptian Annona muricata against Ehrlich ascites carcinoma (EAC) in albino mice which induced by intraperitoneal injection with EAC cells (2×106 cells/mouse). Eighty-eight female adult albino mice were utilized in the beginning of the current study and were separated into five groups, normal control, Ehrlich ascites carcinoma, fruit extract (200 mg/kg), leaf extract (200 mg/kg), and cisplatin (2 mg/kg) treated groups for nine successive days after 48 hours of pre-injection with EAC cells. Viability of tumor ascites cells, the volume of ascites fluid, and EAC cell count were significantly decreased after daily treatment with both extracts. Hematological parameters were enhanced, liver enzymes and creatinine regain their normal values. Oxidative stress was dimensioned via decreasing of lactate dehydrogenase (LDH) and malondialdehyde (MDA). Antioxidant activity was enhanced through the increasing of the total antioxidant capacity (TAC) and reduced glutathione (GSH) concentrations, and the activities of superoxide dismutase (SOD) and catalase (CAT). Histopathologically, residual tumor growth on the outer surface of the liver and kidney were markedly reduced without infiltration onto the tissues. Inflammation of tissues was inhibited and tissue architecture was ameliorated. In conclusion, Annona extracts could have anticancer activity and antioxidant properties which could be useful in dimensioning cancer progression and improves organs protection.

DOI

10.21608/zvjz.2019.12593.1040

Keywords

Anticancer, antioxidant, Annona extract, Ehrlich Ascites Carcinoma

Authors

First Name

Ahmad

Last Name

Hassan

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Port Said University, 42511Egypt

Email

ahkhalaf71@yahoo.com

City

Port Said

Orcid

-

First Name

Lames

Last Name

Mohammed

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Port Said University, 42511 Egypt

Email

lamismohamed65@yahoo.com

City

Port Said

Orcid

-

First Name

Mohammed

Last Name

Abd ElMoneim

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Port Said University, 42511 Egypt

Email

mohammed.abdelmenem@sci.psu.edu.eg

City

-

Orcid

-

First Name

Atef

Last Name

Abd ElBaky

MiddleName

-

Affiliation

Biochemistry Department, Faculty of Pharmacy, Port Said University 42511 Egypt

Email

atef.abdelbaky@pha.psu.edu.egy

City

-

Orcid

-

Volume

47

Article Issue

3

Related Issue

7930

Issue Date

2019-09-01

Receive Date

2019-05-08

Publish Date

2019-09-01

Page Start

234

Page End

247

Print ISSN

1110-1458

Online ISSN

2357-075X

Link

https://zvjz.journals.ekb.eg/article_50986.html

Detail API

https://zvjz.journals.ekb.eg/service?article_code=50986

Order

1

Type

Original Article

Type Code

601

Publication Type

Journal

Publication Title

Zagazig Veterinary Journal

Publication Link

https://zvjz.journals.ekb.eg/

MainTitle

Hepatic and Renal Protective Effects of Annona muricata Leaf and Fruit Extracts on Ehrlich Ascites Carcinoma in Mice

Details

Type

Article

Created At

22 Jan 2023