This work was designed to investigate the possible hypoglycemic effects of ginger (Zingiber officinal) and garlic (Allium sativum) administration on type 2 diabetesinduced in rats. Seventy male adult albino rats were randomly divided into seven groups of ten animals: Normal Control (Cnt), Diabetic Control (CntD), Ginger Low (GNL), Ginger High (GNH), Garlic Low (GRL), Garlic High (GRH) and a combination group (GNH+GRH). Diabetes was induced by an intraperitoneal injection of streptozotocin (STZ, 65 mg/kg of body weight) in all groups except the Cnt group. Rats were treated with ginger and garlic powders in different doses for 2 months. At the end of experiment, glycated hemoglobin (HbA1c), serum glucose, serum insulin, cholesterol, and high density lipoprotein (HDL)concentrations, low density lipoprotein (LDL), liver glycogen and glucagon levels were estimated.Expression of Glucose-6-Phosphatase and Glucokinase genes in liver samples from each group were normalized with housekeeping gene (ß-actin) using reverse transcriptase real time Polymerase chain reaction. Serum insulin and HDL concentrations were significantly (P< 0.05) higherbutbody weight, fasting blood glucose, total cholesterol, LDLand HbA1clevels were significantly (P< 0.05) lower in the Cnt, GNH, GRH and GNH+GRHgroups compared to the CntD, GNL and GRL groups. Liver glycogen level was significantly (P< 0.05) higher and serum glucagon level was significantly (P< 0.05) lower in the combination group only but non significant difference was observed for the other groups. The expression of liver Glucose-6-Phosphatase gene was significantly (P< 0.05) downregulated but the Glucokinase gene was significantly (P< 0.05) upregulated in STZ diabetic rats treated withhigh doses of ginger and garlic powders. This study suggests that ginger and garlic powders can be used to ameliorate type 2 diabetes and might also help in preventing secondary diabetic complications.