Nano-silvers (AgNPs) are widely used in medical and consumer products thanks to their excellent antimicrobial and anti-carcinogenic effects. Sixty mature male albino mice were randomly distributed into six groups (ten per group). The first group was kept as negative control, the 2^nd one was injected with  silver nanoparticles 78 mg/kg BW I/P for 14 days, group 3 was given pomegranate (20 ml/kg BW) orally for 28 days, in the fourth group pomegranate was administrated for 14 days, followed by AgNPs for another 14 days. The fifth one AgNPs were I/P injected for 14 days, followed by pomegranate for another 14 days.  The last group received AgNPs and pomegranate on the same time with the same doses and route of previous groups.  The results revealed that pomegranate has a protective impact on AgNPs toxicity in all groups. These results were clarified the findings of AST, ALT, SOD, CAT, MDA and GPX. The protective and treatment effects of pomegranate in hepatotoxicity were evidenced by regeneration of hepatocyte and kupffur cells.