The present study was carried out to explore the effect of rosemary and licorice alone or in combination with lead acetate on the biochemical parameters of adult male albino rats. A120 rats were equally divided into 6 groups. Group1 was kept as a control group (negative control). Groups 2 and 3 received aqueous extract of rosemary (100 mg/kg BW/day) and licorice (150 mg/kg BW/day) alone, respectively. Group 4 was given lead acetate (0.2%) alone; Group 5 was administrated lead acetate (0.2%) in combination with the aqueous extract of rosemary and Group 6 received lead acetate (0.2%) in combination with licorice. All treatments were given orally in drinking water for 6 weeks. Blood samples were collected at 2^nd, 4^th and 6^th weeks post-treatment. Results showed that chronic lead toxicity caused a significant disturbance in liver and kidney functions, as well as serum antioxidants and immunoglobulins. However, rosemary or licorice extracts restored such changes. This study revealed that lead exposure induced severe oxidative stress and disturbed simultaneously the serum biochemical profile of albino male rats and rosemary or licorice administration improved these disturbances.