This study was conducted to investigate the relationship between the severity of muscular dystrophy, caused by vitamin E and selenium deficiencies in lambs and kids, and their body condition score (BCS). A total of 71 lambs and kids aged from 1-6 months were used; 51 dystrophic animals (38 lambs and 13 kids) and 20 healthy ones (10 lambs and 10 kids). The animal grouping was done on the basis of BCS and the obtained hematological and biochemical alterations. Blood samples were collected after clinical examination to all animals, for performing the clinicopathological studies.  Results showed that the incidence and severity of the disease were higher in rapidly growing and well-nourished lamb (BCS 3.5-4), while the occurrence of the disease in kids was more common in BCS 1-2.5. Regarding biochemical findings, the serum vitamin E, Se, CAT and GSH-Px recorded lower values in dystrophic lambs and kids than the control, while higher values of CPK, CTn I, MDA and NO were recorded with the strongest alterations in good bodily conditioned ones. A significant decrease in serum Mg level in dystrophic kids with BCS 1-3 was also observed. In conclusion, proper nutrition of dam and young without shortage or excess is necessary. Also, vitamin E and se supplementation should be increased in good bodily conditioned and rapidly growing animals than their counterparts to activate the antioxidant system and reduce oxidative stress.