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28662

Some Pharmacological Studies of Ciprofloxacin and Levofloxacin in Rats

Article

Last updated: 03 Jan 2025

Subjects

-

Tags

Academic and Pre-clinical Veterinary Sciences (Physiology, Histology, …rology, Parasitology, Pharmacology, Forensic Medicine and Toxicology)

Abstract

This study was conducted to investigate some pharmacological effects of ciprofloxacin and levofloxacin in their therapeutic and double therapeutic doses on healthy male albino rats. Forty five rats were divided into 5 groups, each of 9 rats, 1st was left as a control, 2nd and 3rd groups received 100 mg/kg BW ciprofloxacin and levofloxacin respectively, orally for 10 successive days (therapeutic dose). The 4th and 5th groups were administrated 200 mg/kg ciprofloxacin and levofloxacin respectively, orally for 10 successive days (double therapeutic doses). Urine analysis and serum biochemical parameters were estimated in addition to histopathological examination of liver and kidneys. The urine analysis revealed that levofloxacin at its therapeutic and double therapeutic doses produced a significant increase in urinary proteins, blood, bilirubin, urobilinogen and urinary ketones while ciprofloxacin doses produced less damage. However, serum biochemical parameters disclosed that levofloxacin is a safer fluoroquinolone than ciprofloxacin; these results were confirmed by histopathological examination of liver and kidneys. Urine analysis despite widely used in human laboratories, it is not a reliable technique; blood biochemical parameters examination and histopathological examination are more dependable.

DOI

10.21608/zvjz.2017.28662

Keywords

ciprofloxacin, Levofloxacin, urinalysis, Liver and kidney functions

Authors

First Name

Abdel-Alim F.

Last Name

Abdel-Alim

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Email

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City

-

Orcid

-

First Name

Mohammed A.

Last Name

Kamel

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Email

kamelma78@gmail.com

City

-

Orcid

0000-0003-3430-1648

First Name

Refaat A.A.

Last Name

Elsayed

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Email

-

City

-

Orcid

-

Volume

45

Article Issue

Supplementary 1

Related Issue

5095

Issue Date

2017-10-01

Receive Date

2019-03-13

Publish Date

2017-10-01

Page Start

172

Page End

180

Print ISSN

1110-1458

Online ISSN

2357-075X

Link

https://zvjz.journals.ekb.eg/article_28662.html

Detail API

https://zvjz.journals.ekb.eg/service?article_code=28662

Order

18

Type

Original Article

Type Code

601

Publication Type

Journal

Publication Title

Zagazig Veterinary Journal

Publication Link

https://zvjz.journals.ekb.eg/

MainTitle

Some Pharmacological Studies of Ciprofloxacin and Levofloxacin in Rats

Details

Type

Article

Created At

22 Jan 2023