The current study was carried out to study the effect of dietary supplementation with Aloe Vera leaves powder (AVLP) as natural feed additives on growth performance, carcass characteristics and immune response of broiler chickens. Ross unsexed one day old (75 gm) broiler chicks (n=90) were randomly divided into five experimental groups; each group with three replicates (18 chicks/group; 6 chicks/replicate). Diets supplemented with AVLP at rates of 0, 1.5, 2.0 and 2.5 % and the last group supplemented with antibiotic (Oxytetracyclin 1 g/kg diet) for 42 days. Body weights and feed residues were monitored weekly. At the end of the trial, three birds/group were euthanized and then blood samples were collected, moreover carcass dressing and visceral organs were collected and weighed. Results revealed that AVLP had no significant (P>0.05) effects on growth performance of broiler chicken. All treated groups showed non-significant (P>0.05) effect on internal organ weights and carcass traits. Diets supplemented with 1.5, 2.0 and 2.5 % of AVLP stimulate the immunity by increasing the phagocytic capacity and antibody titre against Newcastle disease virus when compared with the control group. These results indicated that addition of AVLP in broiler chicken's diets has no adverse effects on growth performance beside it improves the humoral and the cellular immunity