This study was undertaken to determine the occurrence and the zoonotic importance of methicillin resistant Staphylococcus aureus (MRSA) in raw milk of sheep, goats and buffaloes, some dairy products and dairy workers at Ismailia City, Egypt.A total of 150 samples were collected randomly and cultured on Baird Parker agar and CHROMagar MRSA. Culturing on Baird Parker agar, the results revealed that 46.7 % of raw goat milk, 40% of raw sheep milk, 40% of raw buffaloes' milk, 80% of yogurt, 36.7% of ice cream, 63.3% of Kareish cheese and 63.3% of human swabs' samples were contaminated by coagulase positive Staphylococcus aureus. The isolation rates of MRSA on CHROMagar MRSA in relation to the number of the examined samples and the number of S. aureus isolates were (33.3 and 71.4%), (20 and 50%), (13.3 and 33.3%), (40 and 50%), (13.3 and 36.4%), (33.3 and 52.6%) and (13.3 and 21.1%) from the examined milk samples (goat, sheep, and buffaloes), yogurt, ice cream, Kareish cheese and human swabs' samples, respectively. PCR results showed that all the isolates that were classified as MRSA on CHROMagar contained mecA gene. Results of the disk diffusion test revealed that the resistance rates of MRSA strains to penicillin, gentamycin, vancomycin, clindamycin, amikacin,  erythromycin and oxacillin were 91.2%, 67.6%, 14.7%, 94.1%, 91.2%, 82.4%  and 100%, respectively. The effectiveness of some hand cleansing agents against the selected MRSA isolates was assessed. It was found that hand gel rub based on alcohol and triclosan together was the most effective agent. The findings of the present study necessitate exerting more efforts for effective control of MRSA in dairy products.