The current study aimed to determine residues of ciprofloxacin in different rabbit tissues (liver, muscles, kidneys, spleen, heart and lungs) and sera following administration of multiple oral doses. Twenty five rabbits were given the drug at a dose of 5 mg/kg BW for five successive days and then samples were collected at 1^st, 3^rd, 5^th, 7^th, 9^th, 15^th and 21^st day after last oral dose. The results indicated a widespread distribution of ciprofloxacin in the tested tissues except in the heart. The drug remained within the detectable limit till the 3^rd day in most tested tissues, while in kidneys it remained till the 5^th day following the last oral administration of the drug. Therefore, muscles of rabbits could be eaten safely in the 3^rd day post treatment, while liver and kidneys could be eaten safely in the 5^th day after treatment without any hazards on consumers.