This study was carried out to investigate the effects of phytobiotics (Orego-stim®) and their combinations with probiotics and chemical anticoccidial toltrazuril in prevention of coccidiosis in broilers and also to examine these effects on growth performance, some blood biochemical parameters and immunity indices in broiler chickens. Two hundred and forty, one-day old Cobb chicks were used. They were divided into eight equal groups of 30 birds each. The 1st group was non-infested non-treated group. The other groups were inoculated intra-crop with 1x105 sporulated oocysts of field strain of Eimeria spp. on the 8th day of age. The 2nd group was infested non-treated group. The 3rd group was treated with phytobiotics (300 mg/Liter drinking water). The 4th group was treated with probiotic (1 g/ liter drinking water). The 5th group was treated with toltrazuril 2.5 % (7 mg/kg BW. in drinking water). The 6th group treated with phytobiotics plus probiotic. The 7th group treated with phytobiotics plus toltrazuril 2.5 % while, the last group was treated with probiotic beside toltrazuril 2.5 %. Birds received phytobiotics showed better anticoccidial effect, an increase of growth performance parameters (body weight, body weight gain and feed consumption) and decrease of feed conversion ratio. Moreover, an improvement in immunity indices with variable effects on some blood biochemical parameters were resulted. Phytobiotics can be considered a promising high effective anticoccidial, growth promoting and immunomodulating agents.