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7835

Some Immunomodulating Effects of Diclazuril in New Zealand Rabbits

Article

Last updated: 22 Jan 2023

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Subjects

-

Tags

Academic and Pre-clinical Veterinary Sciences (Physiology, Histology, …rology, Parasitology, Pharmacology, Forensic Medicine and Toxicology)

Abstract

 
This study was conducted to investigate the immunomodulating effects of the diclazuril anticoccidial drug (1mg/kg BW) given orally for 5 successive days to rabbits vaccinated with rabbit haemorrhagic viral disease (RHVD). Two blood samples were collected at the 1st, 2nd, 3rd, 7th, 14th and 21st days post drug and vaccine administration to study the effect of diclazuril on the innate immune response (phagocytic activity, serum lysozyme activity and nitric oxide production) and the humoral immune response (serum total proteins, serum albumins, determination of serum globulins and gamma globulins fractions using electrophoretic technique). The results revealed that diclazuril had adverse effect on both the innate and humoral immune response as evidenced by a significant decrease in phagocytic activity, lysozyme activity, nitric oxide production, serum total proteins, globulins and gamma globulins in rabbits. Therefore, diclazuril is not recommended as a chemotherapeutic agent for rabbits.

DOI

10.21608/zvjz.2016.7835

Keywords

diclazuril, cellular, Humoral, Immune, serum proteins

Authors

First Name

Gamal El-Din

Last Name

Shams

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Email

-

City

-

Orcid

-

First Name

Abdel-Alim

Last Name

Abdel-Alim

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Email

-

City

-

Orcid

-

First Name

Nagah

Last Name

Edrees

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Email

-

City

-

Orcid

-

First Name

Abeer

Last Name

Hossny

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Email

abeerhosny26@yahoo.com

City

-

Orcid

-

Volume

44

Article Issue

1

Related Issue

1524

Issue Date

2016-03-01

Receive Date

2018-06-06

Publish Date

2016-03-01

Page Start

85

Page End

90

Print ISSN

1110-1458

Online ISSN

2357-075X

Article File

ZVJZ_Volume 44_Issue 1_Pages 85-90.pdf

PDF . 495.3kB

Link

https://zvjz.journals.ekb.eg/article_7835.html

Detail API

https://zvjz.journals.ekb.eg/service?article_code=7835

Order

10

Type

Original Article

Type Code

601

Publication Type

Journal

Publication Title

Zagazig Veterinary Journal

Publication Link

https://zvjz.journals.ekb.eg/

MainTitle

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Details

Type

Article

Created At

22 Jan 2023