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7833

Preliminary Study on the Effect of Flunixin Administration on Pharmacokinetics of Cefquinome in Diseased Cattle Calves

Article

Last updated: 22 Jan 2023

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Subjects

-

Tags

Clinical Science, Surgery and Veterinary Diseases (Pathology, Clinical…ltry Diseases, Fish Diseases and Management, Surgery, Theriogenology)

Abstract

 
Cefquinome is one of the fourth generations of cephalosporins developed for veterinary use in treatment of respiratory diseases that are considered the second causes of death in calves. Non-steroidal anti-inflammatory drugs such as flunixin (NSAIDs) are widely prescribed with antibacterial agents in multiple drug prescriptions. The present study aimed to investigate the effect of co-administration of flunixin on the disposition kinetics of cefquinome after intramuscular injection in 10 diseased calves (Pasturella heamolytica infected). Cefquinome was injected in a single dose (2 mg/kg BW) in 5 diseased calves alone and coupled with flunixin (1mg/kg BW) in the other 5 diseased calves. Blood samples (5 mL) were collected from the right jugular vein of each calve immediately before treatment and at intervals of 0, 5, 10, 15 and 30 min, 1, 2, 4, 6, 8, 12, and 24 hours, 48, 72, 96 and 120 h (5 days) after cefquinome administration. The obtained samples were assayed with the plate microbiological assay method using Sarcina lutea (ATCC 9341) as test organism. The plasma cefquinome concentration at 5 min after intramuscular injection of cefquinome alone and coupled with flunixin was 0.27 ± 0.05 μg/mL and 0.35 ± 0.12 μg/mL, respectively and reached the highest concentration (1.02 ± 0.12 μg/mL and 1.02 ± 0.08 μg/mL) at 1 h, respectively. The obtained data showed no significant effect of coupled administration of flunixin with cefquinome on either concentration or peak concentration of cefquinome in plasma of diseased calves. It is concluded that flunixin can be used successfully with cefquinome in treatment of bacterial respiratory diseases associated with inflammation in calves.

DOI

10.21608/zvjz.2016.7833

Keywords

Flunixin, cefquinome, Pharmacokinetics, Diseased Calves, Plat Microbiological Assay

Authors

First Name

Mohamed

Last Name

Saber

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Egypt

Email

mohammedsaid0610@gmail.com

City

-

Orcid

-

First Name

Monir

Last Name

Abd-Elhalim

MiddleName

-

Affiliation

Internal Medicine and Infectious Diseases Department, Faculty of Veterinary Medicine, Cairo University, Egypt

Email

-

City

-

Orcid

-

First Name

Shymaa

Last Name

El-Badawy

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Egypt

Email

-

City

-

Orcid

-

First Name

Aziza

Last Name

Amer

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Egypt

Email

-

City

-

Orcid

-

Volume

44

Article Issue

1

Related Issue

1524

Issue Date

2016-03-01

Receive Date

2018-06-06

Publish Date

2016-03-01

Page Start

67

Page End

74

Print ISSN

1110-1458

Online ISSN

2357-075X

Article File

ZVJZ_Volume 44_Issue 1_Pages 67-74.pdf

PDF . 808.5kB

Link

https://zvjz.journals.ekb.eg/article_7833.html

Detail API

https://zvjz.journals.ekb.eg/service?article_code=7833

Order

8

Type

Original Article

Type Code

601

Publication Type

Journal

Publication Title

Zagazig Veterinary Journal

Publication Link

https://zvjz.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023