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7832

Effect of Florfenicol on Hematology, Cardiac Enzymes and its Residues in Broiler Chickens by HPLC

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Last updated: 03 Jan 2025

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Tags

Academic and Pre-clinical Veterinary Sciences (Physiology, Histology, …rology, Parasitology, Pharmacology, Forensic Medicine and Toxicology)

Abstract

 
The current study was conducted on multiple oral doses (40 mg/kg for 3 successive days) of florfenicol (FF) to determine its effect on some hematological parameters, cardiac enzymes and its residues in blood and tissues (liver, muscles and kidneys) of broiler chickens. Seventy broiler chickens were used and divided into two groups, each consisted of 35 birds. The first group was left as a control, while the second was given FF for 3 successive days. The FF residues in tissues were determined using reversed phase-high performance liquid chromatography (RP-HPLC) with ultraviolet (UV) detector at 223 nm. Results indicated a widespread distribution of FF in most of the tested tissues. All tissue samples were considered FF free on the 9th day after the last oral dose except liver. Florfenicol administration elicited a significant decrease in all blood parameters (hemoglobin concentration (Hb), red blood cell count (RBCs), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC) and lymphocytes) from 1st up to 7th day except packed cell volume (PCV) which showed no significant change on 1st day but decreased on 3rd, 5th and 7th day after stopping medication. Moreover, monocytopenia was observed on the 5th and 7th day and white blood cells (WBCs) showed the same effect on the 5th day, while heterophiles revealed highly elevation. All cardiac enzymes (aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase MB (CK-MB) and Troponin I) were highly elevated. In conclusion, broiler chicken meat can be consumed safely after 9 days post FF treatment.

DOI

10.21608/zvjz.2016.7832

Keywords

florfenicol, Broiler Chicken, HPLC Residues, hematological parameters, Cardiac enzymes

Authors

First Name

Ahmed

Last Name

Said

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Email

-

City

-

Orcid

-

First Name

Sameh

Last Name

El-Nabtity

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Email

-

City

-

Orcid

-

First Name

Abdulla

Last Name

Selim

MiddleName

-

Affiliation

Animal Health Research Institute, Dokki, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

Mai

Last Name

Fadel

MiddleName

-

Affiliation

Animal Health Research Institute, Dokki, Giza, Egypt

Email

dr.mai87@yahoo.com

City

-

Orcid

-

Volume

44

Article Issue

1

Related Issue

1524

Issue Date

2016-03-01

Receive Date

2018-06-06

Publish Date

2016-03-01

Page Start

56

Page End

66

Print ISSN

1110-1458

Online ISSN

2357-075X

Article File

ZVJZ_Volume 44_Issue 1_Pages 56-66.pdf

PDF . 613.6kB

Link

https://zvjz.journals.ekb.eg/article_7832.html

Detail API

https://zvjz.journals.ekb.eg/service?article_code=7832

Order

7

Type

Original Article

Type Code

601

Publication Type

Journal

Publication Title

Zagazig Veterinary Journal

Publication Link

https://zvjz.journals.ekb.eg/

MainTitle

Effect of Florfenicol on Hematology, Cardiac Enzymes and its Residues in Broiler Chickens by HPLC

Details

Type

Article

Created At

22 Jan 2023