Beta
ManageSearchChatDiscover
7831

Immunological and Biochemical Profiles of Tilmicosin in Rabbits

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Clinical Science, Surgery and Veterinary Diseases (Pathology, Clinical…ltry Diseases, Fish Diseases and Management, Surgery, Theriogenology)

Abstract

 
This study aimed to evaluate the effect of tilmicosin on rabbit immunity after daily subcutaneous (S.C) injection for 3 successive days. Fifteen New Zealand male rabbits were divided into 3 groups; the first group was left as a control, the second was non treated vaccinated against pasteurellosis (1 mL S.C in the skin fold of the back of the rabbit), while, the third was vaccinated and treated by tilmicosin in a dose of 10 mg/kg BW daily for 3 days. Whole blood and serum samples were collected from each rabbit on 1st ,3rd ,9th ,14th ,21st and 28th days post drug administration to determine some immunological and biochemical parameters. Histopathological examination of liver, kidneys and heart of all groups was also carried out. The results revealed that tilmicosin elicited a significant increase in B-lymphocytes, nitric oxide production by macrophages and lysozyme activity of the serum. Meanwhile, the drug had no significant changes on alanine aminotransferase enzyme (ALT) and aspartate aminotransferase enzyme (AST) levels (liver enzymes). On the 21st day ALT showed significant decrease. Moreover; there were no significant changes on urea and creatinine levels (kidney functions) when compared with control group. Histopathological findings of the vaccinated and treated groups showed lesion score from 1st and 2nd degree. It could be concluded that tilmicosin afforded a good effect on rabbits' immunity without negative effects on liver and kidney functions.

DOI

10.21608/zvjz.2016.7831

Keywords

tilmicosin, Pasteurollosis, New Zealand Rabbits, Lysozyme activity, lymphocyte, liver enzymes

Authors

First Name

Ahmed

Last Name

Said

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Email

-

City

-

Orcid

-

First Name

Abdel-Alim

Last Name

Abdel-Alim

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Email

-

City

-

Orcid

-

First Name

Sameh

Last Name

El-Nabtity

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Email

-

City

-

Orcid

-

First Name

Manal

Last Name

Eldin

MiddleName

-

Affiliation

Reproduction Research Institute, Al Haram, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

Mai

Last Name

Fadel

MiddleName

-

Affiliation

Animal Health Research Institute, Dokki, Giza, Egypt

Email

dr.mai87@yahoo.com

City

-

Orcid

-

Volume

44

Article Issue

1

Related Issue

1524

Issue Date

2016-03-01

Receive Date

2018-06-06

Publish Date

2016-03-01

Page Start

48

Page End

55

Print ISSN

1110-1458

Online ISSN

2357-075X

Article File

ZVJZ_Volume 44_Issue 1_Pages 48-55.pdf

PDF . 248.7kB

Link

https://zvjz.journals.ekb.eg/article_7831.html

Detail API

https://zvjz.journals.ekb.eg/service?article_code=7831

Order

6

Type

Original Article

Type Code

601

Publication Type

Journal

Publication Title

Zagazig Veterinary Journal

Publication Link

https://zvjz.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023