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7829

Detection of Tilmicosin Residues by HPLC and its Effect on Cardiac Enzymes and Hematology in Broiler Chickens

Article

Last updated: 22 Jan 2023

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Subjects

-

Tags

Academic and Pre-clinical Veterinary Sciences (Physiology, Histology, …rology, Parasitology, Pharmacology, Forensic Medicine and Toxicology)

Abstract

 
The aim of the present study was to detect the tilmicosin residues in muscles, kidneys and liver of broiler chickens and to investigate its impact on both cardiac enzymes and some hematological parameters. Seventy broiler chickens were divided into two groups; the first was left as a negative control. The second group was given tilmicosin orally (30 mg/kg BW) once/day for three successive days. Reversed phase-high performance liquid chromatography (RP-HPLC) with UV detector at 287 nm and solid phase extraction were used for detecting drug residues in tissue samples. Results indicated a widespread distribution of tilmicosin in most tested tissues. All tissue samples were considered tilmicosin free at the 9th day after the last oral dose except liver. Tilmicosin elicited a significant reduction in red blood cells count, hemoglobin concentration, packed cell volume, lymphocytes and eosinophiles. On the other hand, heterophiles count and the mean corpuscular volume were increased significantly. White blood cells, monocytes, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration showed non-significant changes. Levels of all cardiac enzymes (Aspartate aminotransferase, lactate dehydrogenase, creatine kinase-MB and Troponin I) were high.

DOI

10.21608/zvjz.2016.7829

Keywords

Tilmicosin Residues, hematological parameters, Cardiac enzymes, broiler, HPLC

Authors

First Name

Ahmed

Last Name

Said

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Email

-

City

-

Orcid

-

First Name

Sameh

Last Name

El-Nabtity

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Email

-

City

-

Orcid

-

First Name

Abdulla

Last Name

Selim

MiddleName

-

Affiliation

Animal Health Research Institute, Dokki, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

Mai

Last Name

Fadel

MiddleName

-

Affiliation

Animal Health Research Institute, Dokki, Giza, Egypt

Email

dr.mai87@yahoo.com

City

-

Orcid

-

Volume

44

Article Issue

1

Related Issue

1524

Issue Date

2016-03-01

Receive Date

2018-06-06

Publish Date

2016-03-01

Page Start

29

Page End

39

Print ISSN

1110-1458

Online ISSN

2357-075X

Article File

ZVJZ_Volume 44_Issue 1_Pages 29-39.pdf

PDF . 532.7kB

Link

https://zvjz.journals.ekb.eg/article_7829.html

Detail API

https://zvjz.journals.ekb.eg/service?article_code=7829

Order

4

Type

Original Article

Type Code

601

Publication Type

Journal

Publication Title

Zagazig Veterinary Journal

Publication Link

https://zvjz.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023