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7885

Ameliorative Effect of Mesenchymal Stromal Cells on Diabetic Nephropathy in Male Rats

Article

Last updated: 22 Jan 2023

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Tags

Clinical Science, Surgery and Veterinary Diseases (Pathology, Clinical…ltry Diseases, Fish Diseases and Management, Surgery, Theriogenology)

Abstract

Both types of diabetes mellitus (DM) are recognized by the destruction of pancreas or deficient function of Islets' cells causing several complications. Diabetes mainly affect the kidney leading to diabetic nephropathy (DN) in the late renal stage, which caused higher mortality in diabetic patients. Since diabetic disease appearance, nephropathy may be observed in patients with type 1 or 2 diabetes. Recently, cell culture can be used in the regenerative medicine as a new method for treating diabetes and DN. Therefore, the aim of the current study was to prove the beneficial effect of mesenchymal stromal cells (MSCs) transplantation on DN during the early stage. Male rats were randomized in 3 groups (each 20 rats): the 1st group was normal rats, while the 2nd was streptozotocin (STZ) diabetic rats and the 3rd was diabetic rats treated with a single intravenous dose of bone marrow mesenchymal stromal cells (BM-MSCs) after 3 days from STZ induction. Results indicated that STZ induced DN represented by weight loss, hyperglycemia, hypoinsulineamia, decreased glycated hemoglobin, leukocytosis and impairment of kidney function and oxidative stress in kidney tissue. After BM-MSCs treatment, blood glucose level was improved, renal function was retained, body weight loss was decreased, insulin level and HBA1C percent were ameliorated with improved oxidative stress in kidney tissue. BM-MSCs have the capacity to regenerate and differentiate into insulin- producing cells improving DM and DN.

DOI

10.21608/zvjz.2017.7885

Authors

First Name

Ahmed

Last Name

Mansour

MiddleName

M.

Affiliation

Pharmacology and Toxicology Department, Faculty of Pharmacy (Boys) – Al-Azhar University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Hussein

Last Name

El-belbasi

MiddleName

I.

Affiliation

Biochemistry Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Email

-

City

-

Orcid

-

First Name

Hamad

Last Name

El-saadawy

MiddleName

A.

Affiliation

Biochemistry Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Email

-

City

-

Orcid

-

First Name

Engy

Last Name

Yassin

MiddleName

M.M.

Affiliation

Biochemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt

Email

mohamec_amin2006@yahoo.com

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

1520

Issue Date

2017-06-01

Receive Date

2017-03-01

Publish Date

2017-06-01

Page Start

125

Page End

133

Print ISSN

1110-1458

Online ISSN

2357-075X

Article File

ZVJZ_Volume 45_Issue 2_Pages 125-133.pdf

PDF . 542.1kB

Link

https://zvjz.journals.ekb.eg/article_7885.html

Detail API

https://zvjz.journals.ekb.eg/service?article_code=7885

Order

4

Type

Original Article

Type Code

601

Publication Type

Journal

Publication Title

Zagazig Veterinary Journal

Publication Link

https://zvjz.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023