Polycystic ovaries syndrome (PCOS) is one of the most prevalent causes of reproductive failure. Its pathogenesis may be hormonal and immune disorder with hyperactivity of the sympathetic nervous system. The present study was conducted to demonstrate the effect of coleus forskohlii roots extract (CFE) in modulating the levels of some hormones and immune parameters of rats with androgen induced PCOS. Fifty immature female albino rats were divided into control group and androgen treated group that injected subcutaneously with 60 mg/kg BW/day androgen (Cidotestone) for 35 days to induce PCOS. Each group was subdivided into two subgroups. The first two subgroups received saline and 25 mg/kg BW of CFE, respectively while the other two subgroups received the same doses of Cidotestone and Cidotestone + CFE, respectively for 3 weeks. Blood samples were collected at the end of the experiment to estimate the levels of corticosterone, beta endorphin, total leucocytic count (TLC), cluster of differentiation 4 (CD⁺4), cluster of differentiation 8 (CD⁺8), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), immunoglobulin G (IgG) and immunoglobulin A (IgA). The results revealed a significant decrease in the concentrations of β endorphin, IL-2, TLC, CD⁺4, CD⁺8 and IgG, while corticosterone and IL-4 showed a significant increase in the androgen induced PCOS group. Rats treated with Cidotestone + CFE displayed normal values of all tested parameters except corticosterone, suggesting role of CFE in mediating both humoral and cellular immunity.