The current study aimed to investigate the possible effect of Ceratonia siliqua (carob) pods and Ficus carica (fig) fruits ether extracts against lead toxicity on hematological, biochemical parameters, growth performance and mortality % in Nile Tilapia (Oreochromis niloticus). One hundred and forty fish were divided into 7 groups. The first group was left as a control and fed a control diet, while, the second and third groups were exposed to 1/2 96 h LC₅₀ (77.5 mg/L) and 1/4 96 hLC₅₀ (38.7 mg/L) of Lead (Pb), respectively and provided with a control diet. The fourth and fifth groups were exposed to 1/2 96 h LC₅₀ and 1/4 96 h LC₅₀ of Pb, respectively and fed diet with 600 mg carob extract/kg diet. The sixth and seventh group were exposed to 1/2 96 h LC₅₀ and 1/4 96 h LC₅₀ of Pb, respectively and provided with diet contain 600 mg fig extract/kg diet. The hematological, biochemical parameters and growth performance was significantly decreased after exposure to 1/2 96 h LC₅₀ and 1/4 96 hLC₅₀ of Pb for 30, 60 and 90 days, while plasma glucose and mortality % were increased significantly. There were no significant changes in RBCs, Hb and PCV of O. niloticus exposed to 1/2 96 h LC₅₀ and 1/4 96 h LC₅₀ of Pb that fed diet enriched with carob extract 600 mg/kg diet for 90 days. The fish exposed to 1/2 96 h LC₅₀ and 1/4 96 h LC₅₀ of Pb and fed diet enriched with 600 mg/kg diet carob or fig for 90 days revealed no significant changes in plasma albumin, total protein, glucose and growth parameters with a reduction of mortality %. The current study highlighted the importance of carob and fig ether extract in the protection of Nile tilapia against the lead acetate toxicity.