Salinity causes physiological, morphological, and anatomical modifications in Mediterranean saltbush Atriplex halimus and giant saltbush Atriplex nummularia. Both species, which belong to Chenopodiaceae, are true xerophyte as shown from Kranz-anatomy and salt storage trichromes. Response of both species to salinity were differed according to genetic structures. Atriplex species leaves characteristic by presence of salt accumulating cells on upper and lower leaf epidermis, which have ecological significance. Increasing of salinity had negative effect on anatomical measurements of A. halimus leaves. However, low level of salinity had positive effect in A. nummularia leaves, but high level of had negative effect on leaves.