The aims of the current study were to estimate the effect of inbreeding and genetic parameters of birth weight (BW), preweaning daily gain (PDG) and weaning weight (WW) in buffalo calves. Data were collected from weight records of buffalo calves raised at Mahallet Mousa Farms belonging to the Animal Production Research Institute. It included 2015 progeny of 125 sires, through 17 consecutive years. Effect of inbreeding was highly significant for all studied traits. The overall average of inbreeding coefficient was 0.53% in whole population and 15% in the inbred animals. The means of BW, PDG and WW in non-inbred group were 37.318, 0.490 and 88.86 Kg, respectively. While, the means of the same traits in inbred group were 31.96, 0.446 and 78.82 Kg, respectively. Corresponding the inbreeding depression as overall means of levels for above traits were -0.350, -0.003 and -0.716, respectively. Direct heritability (h²_a) in inbred animals for BW, PDG and WW were 0.28, 0.25 and 0.19, respectively. On the other hand, the h²_a of studied traits in non-inbred animals were 0.32, 0.30 and 0.23, respectively. The maternal heritability (h²_m) for mentioned traits were 0.25, 0.26 and 0.21 within inbred animals and 0.29, 0.28 and 0.22 within non-inbred animals, respectively. Likewise, the genetic correlations (r_g) among studied traits were ranged from (0.12 to 0.56) in inbred animals and were ranged from (0.16 to 0.63) in non-bred animals. As well the phenotypic correlation (r_{p < /sub>) among studied traits were ranged from (0.04 to 0.50) for inbreds and were varied between (0.04 and 0.54) for non-inbreds. The inbreeding was pronounced detrimental effects of studied traits in buffalo calves. Therefore, breeding strategies should be develop for reduce the inbreeding effects and inclusion the effects of inbreeding in genetic evaluation programs in Egyptian buffalo calves.}