The archeological sites in El-Kharga oasis represent a tangible cultural heritage of outstanding universal value. Such monuments have suffered environmental and climatic hazards, especially the climate extreme and climate change throughout thousands of years. The current research focuses on determining the deterioration response that has occurred for hundreds of years to the impacts of environmental and climatic hazards in El-Kharga oasis since the Twenty-sixth Dynasty (664 BC) such as the temple of Hibis and beyond many Greek-Roman temples of 13 largest archeological sites (i.e. Umm El Dabadeb, Ain Amur, El-Nadoura, Kasr El-Zayyan, Doush temple, Deir El Monira, Ain El Labkha, Kasr El-Ghawieta, El Gib, Qasr El Somira, Al Tarakwa, El Dabashya and Remains of prehistoric times as in Gebel el-Teir). The current study aims to determine the environmental hazards that affect archaeological sites that represent a tangible cultural heritage in the study area under investigation, to understand and predict the type, nature, and magnitude of environmental hazards that affect the archeological sites in El-Kharga oasis. The fieldwork was accomplished with laboratory tests for some rock samples selected from sites with delegated weathering type and deterioration group of all the archeo-logical sites under investigation. Seventy-one samples have been tested by X-ray diffraction analysis (XRD), polarizing microscopy (PLM), and scanning electron microscopy equipped with an energy-dispersive X-ray analysis system (SEM-EDX). Based on the results of the current study, it has been concluded that most archaeological sites under investigations have reached the categories of severe damage, based on laboratory analyzes and periodic field studies. The present study concluded that there are several potential environmental hazards with significant impact on archaeological areas in El-Kharga oasis include (weathering hazard represents 45%, underground water hazard represents 18%, sand encroachment hazard represents 12%, human-induced hazard represents 15% and climate extremes and climate change hazards represent 10%) of total deterioration ratios, and in some cases, through graffiti.