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Methylenetetrahydrofolate Reductase and Peroxisome Proliferator-Activated Receptor-γ Gene Polymorphisms and Risk of Obesity in Females of Madina, Saudi Arabia

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Last updated: 24 Dec 2024

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Abstract

Aim: The aim of this study is to evaluate the association of polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and peroxisome proliferator-activated receptor (PPAR) genes with obesity among adult females in Al-Madina, Saudi Arabia. Method: The participants in this study were 114 healthy females aged 18–60 years. Body mass index (BMI) and body composition parameters were assessed. Triglycerides, total cholesterol, HDL, and LDL were measured. Real-time PCR was used to detect the selected genetic polymorphisms of PPAR-γ rs1801282 and MTHFR rs1801131. Results: Weight, BMI, fat-percentage, FFM, truncal fat mass, and LDL were significantly higher in the overweight and obese group than in the normal BMI group. PPAR-γ genotype and allele polymorphism frequencies in the overweight and obesity group showed no statistically significant differences compared to those of the normal weight group. However, a significant difference was found between the frequency of both T and G alleles of MTHFR in the normal BMI and overweight and obese group (p = 0.03) and a significant correlation with the fat-percentage in both groups (p = 0.01). A significant correlation between the MTHFR genotypes and the fat-percentage in both groups was also found (p = 0.04). Conclusion: In this population of Saudi females, we found that MTHFR GG genotype and G allele are significantly correlated with the deposition of fat in the body; women with this allele and genotype should be advised to control their weight and fat intake, as this is also associated with LDL levels that may affect their cardiovascular system.

DOI

10.21608/besps.2022.171402.1130

Keywords

Obesity, Polymorphism, PPAR-γ, MTHFR

Authors

First Name

Moutasem

Last Name

Aboonq

MiddleName

S.

Affiliation

Department of Medical Physiology, Faculty of Medicine, Taibah University, Al-Madina Al Monawarah, Saudi Arabia.

Email

aboonq@yahoo.co.uk

City

-

Orcid

-

First Name

Magda

Last Name

Youssef

MiddleName

H.M.

Affiliation

Department of Medical Physiology, Faculty of Medicine, Taibah University, Al-Madina Al Monawarah, Saudi Arabia.

Email

mhm.youssef@gmail.com

City

-

Orcid

-

First Name

Sherif

Last Name

El-Kafrawy

MiddleName

A.

Affiliation

Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Email

saelkfrawy@kau.edu.sa

City

-

Orcid

-

First Name

Tamer

Last Name

Hifnawy

MiddleName

-

Affiliation

Medical Education Department, College of Dentistry, Taibah University, Al Madinah Al Monawarah, Saudi Arabia.

Email

thifnawy@yahoo.com

City

-

Orcid

-

First Name

Moaz

Last Name

Mojaddidi

MiddleName

-

Affiliation

Department of Medical Physiology, Faculty of Medicine, Taibah University, Al-Madina Al Monawarah, Saudi Arabia.

Email

moaz.mojaddidi@gmail.com

City

-

Orcid

-

First Name

Eman

Last Name

A-Fadhly

MiddleName

-

Affiliation

Department of Medicine, College of Medicine, Taibah University, Al Madinah Al Monawarah, Saudi Arabia.

Email

alfadhli2005@yahoo.com

City

-

Orcid

-

First Name

Shereen

Last Name

Eltarhony

MiddleName

-

Affiliation

Medical biochemistry department, Faculty of Medicine, Zagazig university

Email

shereeneltarhony@hotmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

ElGendy

MiddleName

Abdulhakim

Affiliation

Department of Medical Physiology,Faculty of Medicine,Mansoura University,Mansoura ,Egypt.

Email

ahmedabdelhakim1994@outlook.sa

City

Mansoura

Orcid

0000-0002-3896-9023

First Name

Elsayed

Last Name

Eid

MiddleName

A.

Affiliation

Department of endocrinology and internal Medicine Department, Delta University, Gamasa, Egypt

Email

sayedeid92@yahoo.com

City

-

Orcid

-

Volume

43

Article Issue

1

Related Issue

38593

Issue Date

2023-01-01

Receive Date

2022-10-28

Publish Date

2023-01-01

Page Start

64

Page End

74

Print ISSN

1110-0842

Online ISSN

2356-9514

Article File

BESPS_Volume 43_Issue 1_Pages 64-74.pdf

PDF . 676.3kB

Link

https://besps.journals.ekb.eg/article_277758.html

Detail API

https://besps.journals.ekb.eg/service?article_code=277758

Order

277,758

Type

Original Article

Type Code

567

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

Methylenetetrahydrofolate Reductase and Peroxisome Proliferator-Activated Receptor-γ Gene Polymorphisms and Risk of Obesity in Females of Madina, Saudi Arabia

Details

Type

Article

Created At

22 Jan 2023