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211887

COVID-19, Wide Spread and Treatment Need

Article

Last updated: 24 Dec 2024

Subjects

-

Tags

Cell Physiology

Abstract

Human coronavirus, hCoV-19, is highly pathogenic with severe pneumonia linked to rapid replication of the virus and worldwide spread. Originating in Wuhan China December 2019, the current COVID-19 epidemic has grown rapidly with individual-to-person infection expanding to become a pandemic-scale global health emergency. As a pandemic, COVID-19 has led many researchers from various areas of biomedicine to pursue approaches or therapies to handle the pandemic. COVID-2019 cure is in part based on the patient's own immune system. When the over-activated immune system kills the virus, a large number of inflammatory factors are produced which lead to severe cytokine storms. This appears that the key explanation for damage to these organs may be due to a cytokine storm caused by the virus. Current therapies available-including non-specific anti-viral, antibiotics to treat secondary bacterial infections and sepsis, and inflammatory corticosteroids-fail in serious disease where the hallmark is the COVID-19-induced cytokine storm in the lung. Until now, however, no specific treatment has been found for this disease. Thus, there is a significant unmet need for safe and efficient care.

DOI

10.21608/besps.2021.51022.1086

Keywords

COVID-19, immunomodulatory, cytokine storms, Treatment, Investigational Drugs

Authors

First Name

Eman

Last Name

El-Shafey

MiddleName

Salah

Affiliation

Damietta University Faculty of Science

Email

emansalah_2008@yahoo.com

City

-

Orcid

0000-0002-9674-7832

First Name

Eslam

Last Name

Elsherbiny

MiddleName

Samy

Affiliation

Damietta university Faculty of Science

Email

eslamsamy1@yahoo.com

City

-

Orcid

-

Volume

42

Article Issue

1

Related Issue

29627

Issue Date

2022-01-01

Receive Date

2020-11-24

Publish Date

2022-01-01

Page Start

1

Page End

10

Print ISSN

1110-0842

Online ISSN

2356-9514

Link

https://besps.journals.ekb.eg/article_211887.html

Detail API

https://besps.journals.ekb.eg/service?article_code=211887

Order

1

Type

Review Article

Type Code

574

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

COVID-19, Wide Spread and Treatment Need

Details

Type

Article

Created At

22 Jan 2023