Background: Diabetes Mellitus is the most common endocrine disorder. It is a pathological state leads to long term complications causing damage of different tissue and organs as heart and blood vessels. Ginger is one of the most important plants with several medicinal, nutritional and ethnomedical values. Cinnamon contains proteins, carbohydrates, vitamins [A, C, K, B3], Minerals like Calcium, Iron, Magnesium, Manganese, Phosphorous, Sodium and Zinc. Aim of the work: Evaluation the effects of ginger and cinnamon extracts administration on diabetic adult male albino rats. Materials and Methods: Seventy adult male albino rats of local strain were divided into equal seven groups as follow: Group I: served as control group received normal saline, Group II: high fat diet control group, Group III: high fat diet diabetic control group, Group IV: High fat diet, diabetic and metformin group, Group V: high fat diet, diabetic and ginger group, Group VI: high fat diet, diabetic and cinnamon group and Group VII: high fat diet, diabetic, ginger and cinnamon group. Results: Metformin, ginger and cinnamon administration to diabetic rats leads a significant decrease of blood glucose level, glycated hemoglobin level, cholesterol, TG, LDL, atherosclerosis index, atherogenic index, MDa, TNF α and CRP levels associated with significant increase in serum insulin and catalase levels. Conclusion: Metformin, ginger and cinnamon have a protective effect against abnormalities in diabetic rats due to its antioxidant properties.