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67939

Sex Differences in Metabolic Responses to Chronic Immobilization Stress in Rats

Article

Last updated: 03 Jan 2025

Subjects

-

Tags

Comparative Physiology

Abstract

Background: Responses to stress could range from homeostatic variations to life-threatening effects. Gender is accompanied by variations in oxidative stress that are implicated in the development of metabolic diseases. Females were found to be less susceptible to oxidative stress.
Aim: to clarify the differences in metabolic responses to chronic immobilization stress in both rat sexes, and to elucidate the possible underlying mechanism.
Methods: 40 adult albino rats of both sexes were divided into 2 main groups: control and stressed groups, each was subdivided into male and female groups. Stressed groups were exposed to immobilization for 4 weeks. All rats were subjected to estimation of body mass index percentage change (BMI%), visceral fat weight (VFW), glycemic parameters, lipid profile, plasma insulin, leptin, sex hormones, malondialdehyde (MDA), total antioxidant capacity (TAC) and nitrite. HOMA-B and HOMA-IR were calculated, Caspase-3 was assessed in pancreas by immunohistochemistry.
Results: Stressed male rats showed lower BMI%, VFW, dyslipidemia, hyperglycemia, higher glucose output by kidneys, lower glucose uptake by diaphragm, HOMA-B, plasma insulin, testosterone and TAC, with higher plasma estrogen and MDA levels compared to control male group. Compared to control females, stressed females exhibited lower VFW, hyperglycemia, hypoinsulinemia, dyslipidemia, lower plasma TAC and HOMA-B, with higher nitrite and sex hormones. Compared to stressed males, stressed females showed higher BMI%, plasma TAC and estrogen, but lower glucose output by kidneys, dyslipidemia and testosterone.
Conclusion: Chronic immobilization stress imposes greater metabolic derangement in males than in females. The altered sex hormones and lowered antioxidants could be contributory mechanisms.

DOI

10.21608/besps.2019.18674.1036

Keywords

Gender, Immobilization stress, Metabolic disorders, Oxidative Stress, Sex hormones

Authors

First Name

Ienass

Last Name

Bahaa El-Dein

MiddleName

Mohamed

Affiliation

Physiology department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

ienassbahaa@yahoo.com

City

cairo

Orcid

-

First Name

Fatma

Last Name

Mohamed

MiddleName

Ahmed

Affiliation

Physiology department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

drmona_agha70@yahoo.com

City

Cairo

Orcid

-

First Name

Mona

Last Name

Ahmed

MiddleName

Ahmed

Affiliation

Physiology department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

drmonaagha70@gmail.com

City

Cairo

Orcid

0000000172370105

First Name

Nevine

Last Name

Soliman

MiddleName

Bahaa El-Dein

Affiliation

Histology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

nevine_bahaaeldine@med.asu.edu.eg

City

Cairo

Orcid

0000-0001-7343-2072

First Name

Noha

Last Name

Lasheen

MiddleName

Nooh

Affiliation

Physiology department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

nlashen@yahoo.com

City

Cairo

Orcid

0000-0002-5418-2191

First Name

Doaa

Last Name

Abou-Bakr

MiddleName

Ahmed

Affiliation

Physiology department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

doaa1510@gmail.com

City

Cairo

Orcid

0000-0002-8356-4148

Volume

40

Article Issue

1

Related Issue

10173

Issue Date

2020-01-01

Receive Date

2019-10-27

Publish Date

2020-01-01

Page Start

148

Page End

165

Print ISSN

1110-0842

Online ISSN

2356-9514

Link

https://besps.journals.ekb.eg/article_67939.html

Detail API

https://besps.journals.ekb.eg/service?article_code=67939

Order

10

Type

Original Article

Type Code

567

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

Sex Differences in Metabolic Responses to Chronic Immobilization Stress in Rats

Details

Type

Article

Created At

22 Jan 2023