In the present study, the role of decreased renal function on resistin was explored.
The possible links with inflammation and the insulin resistance present in patients
with chronic kidney disease (CKD) were investigated. Post-transplantation changes
in these factors and relations were also examined. The study included 83 subjects;
67 patients suffering from chronic kidney diseases and 16 healthy subjects.
Participants were classified into the following groups: Group I:16 chronic kidney
disease patients on conservative treatment (9 males and 7 females, mean age 42.75 ±
11.7 years). Group II:26 dialysis patients (13 males and 13 females, mean age 43.8 ±
14.6 years). Group III:25 post kidney transplantation patients (13 males, 12 females,
mean age 44.2 ± 8.2 years). Group IV:16 healthy, age and sex matched subjects
served as control group (8 males and 8 females, mean age 43.50±9.2 years).
Estimated glomerular filtration rate (eGFR) was calculated by Modification of Diet
in Renal Disease (MDRD) formula. Insulin resistance was estimated using the
homeostasis model assessment for insulin resistance (HOMA-IR) index. Serum levels
of resistin, hs CRP and IL6 were estimated by ELISA technique. Results showed that
circulating resistin levels were significantlyhigher in patient groups compared to the
control group. They decreased significantly post-transplantation, yet still higher than
normal subjects. These levels showed significantly negative correlation with eGFR.
However, resistin levels correlated significantly positive with inflammatory
biomarkers (IL6 and hs CRP) in the studied groups. On the other hand, there was no
significant correlation between resistinand insulin resistance in any group.In
conclusion:Resistin levels correlate with renal function and inflammation in CKD
patients. However, it is not a likely mediatorof insulin resistance in those patients.
Renal function is an important factor to take into account in clinical studies relating
insulin sensitivity to inflammatory biomarkers in CKD