Objectives: Disturbance in the Low-density lipoprotein cholesterol (LDL-C), High-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triglyceride (TG) and
serum total homocysteine are predisposing factors in myocardial infarction.Design
and methods: The study group consisted of 56 patients 35 male (aged 47.8±4.8
years), and 21 females (aged 46±4.3 years). The entry criterion for the patient group
has a history of typical or atypical chest pain, unequivocal changes in the
electrocardiogram. The control group consisted of 30 normal volunteers, 16 male
(aged 48.4±5.2 years) and 14 females (aged 45.1±4.9 years). Measurement of serum
total homocysteine was performed by enzyme linked immune sorbant assay (ELISA).
Measurement of TC, TG, and HDL-C were performed using spectrophotometer. LDL-C
was calculated.Results: Patients with myocardial infarction were found to have
higher serum total homocysteine levels (23.93±2.99 mol/L in male and 25.82±3.82
mol/L in female) than controls (10.45±2.73 mol/L and 12.92±0.9 mol/L in both
male and female respectively) (for each comparison; p < 0.001). Serum total
homocysteine levels were significantly correlated with high Triglycerides and low
HDL-C.Conclusions: The above mentioned findings suggest the potential usefulness of
Triglycerides, HDL-C and serum total homocysteine as risk factors in myocardial
infarction patients. These findings shouldbe used in the future studies on the etiology
and pathogenesis of myocardial infarction and toascertain which patients are at risk
for subsequent cardiovascular events and who will benefit from revascularization.