The ameliorative activity of zinc acetate on thioacetamide–induced hepatotoxicity
was studied in rats. Forty male rats were divided into four equal groups each of 10.
Two groups were controls, one treated withthioacetamide and one with only distilled
water. Two groups received zinc acetate and intraperitoneal (IP) thioacetamide (400
mg/kg b.wt.) either before or after administration of zinc acetate. Liver damage was
assessed by estimation of plasma concentration of bilirubin and enzymes activities of
aspartate aminotransferase, alanine aminotransferase, and hepatic glutathione, MDA
levels; SOD and catalase activities. Treatment with zinc acetate signifcantly reduced
thioacetamide–induced elevation in plasma bilirubin concentration and enzymes
activities. It could be suggested that thioacetamide–induced liver damage in rats
could be ameliorated by treatment with zinc acetate.